When it comes to losing weight, both Mounjaro and Wegovy have shown impressive results in clinical trials. Mounjaro, during studies, exhibited a substantial weight loss ranging from 21% to 22.5% at its highest dosage—a figure similar to the weight reduction achieved through bariatric surgery. In contrast, Wegovy resulted in an average weight loss of around 15% in adults. While direct head-to-head comparisons are limited, the research suggests that Mounjaro's highest dose tends to outperform Wegovy in terms of weight loss.